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3/20/2014 6:14:00 AM

Science Codex: Inhibition of oral biofilm and cell-cell communication using natural-products derivatives

Science Codex

Alexandria, Va., USA – Today during the 43rd Annual Meeting & Exhibition of the American Association for Dental Research, held in conjunction with the 38th Annual Meeting of the Canadian Association for Dental Research, Steve Kasper, SUNY College of Nanoscale Science and Engineering, Albany, will present research titled "Inhibition of Oral Biofilm and Cell-cell Communication Using Natural-products Derivatives."

Many plant metabolites and structurally similar derivatives have been identified as inhibitors of bacterial biofilm formation and quorum sensing (QS). Previously, the researchers of this study demonstrated biofilm and QS inhibition using modified cysteines, similar to those produced by the tropical plant Petiveria alliacea. In this study the researchers expanded their compound library to examine structure-activity relationships for biofilm and QS inhibition.

Using a microplate-based screening approach, they observed the biofilm formation by three indigenous oral Gram-positive bacteria: Streptococcus mutans UA159, Streptococcus sanguis 10556, and Actinomyces oris MG1. Bacteria were grown in the presence of inhibitory compounds and analyzed using fluorescent staining for biomass and via confocal microscopy.

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