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Scott Tenenbaum

Dr. Scott Tenenbaum
Associate Professor of Nanobioscience

Dr. Scott Tenenbaum Discusses Nanobioscience at

Read Governor Andrew Cuomo's press release on an RNA technology co-invented by Professor Tenenbaum that is being developed by Albany-based Hocus Locus, LLC

Read Professor Tenebaum's Nanotechnology Now Column: Using Nanotechnology to Study the Human Genome


  • Postdoctoral Fellow, Duke University Medical Center, Durham, NC, 2003 
  • Postdoctoral Fellow, Tulane University Medical Center, New Orleans, LA, 1997
  • Ph.D., Microbiology and Immunology, Tulane University, New Orleans, LA, 1994 


  • Assistant Professor, Department of Biomedical sciences, University at Albany - State University of New York, Rensselaer, NY, 2003-2009
  • Senior Research Associate, Department of Molecular Microbiology and Genetics, Duke University Medical Center, Durham, NC, 2000-2003 

Research Website: http://sxrna.sunycnse.com/nanobio/tenenbaum/

Areas of Research

  • Studying the mRNP Regulatory Code
  • Development of a high-throughput nanoscale immunoassay platform
  • Development of an Anti-Viral Therapeutic Technology
  • Development of Data Mining Software
  • Prostate Cancer Therapy Drug Study
  • Genomics
  • Single-cell Nanotube sensors
  • Cancer metastasis diagnostics
  • RNA-based therapeutics

Research Description

Dr. Tenenbaum's research focuses on understanding some of the basic aspects of how the human genome works; specifically post-transcriptional gene regulation.  Along with his research team, Dr. Tenenbaum has helped to advance cutting-edge technology and computer-based informatic approaches to studying RNA biology, specifically RNA-binding proteins, to aggressively study and better understand these molecules that regulate information contained in RNA.  Dr. Tenenbaum's research methods also include working on nano-based technology to make the research more robust.  Dr. Tenenbaum is involved with HocusLocus Inc., a biotechnology based start-up company that was spun-out of UAlbany.  Hocus Locus is working to commercialize SUNY RF owned sxRNA intellectual property. sxRNA is a platform technology with many potential applications, including antiviral and cancer therapeutics.

Recent Honors and Awards:

  • Excellence in Research Award, University at Albany
  • Rising Star Award, The Research Foundation of SUNY
  • Golden Apple Teaching Award, UAlbany School of Public Health
  • Robert & Barbara Bell Science of Cancer Award, Duke Comprehensive Cancer Center 
  • James A. Wilson, M.D. Fellow in Cancer Award, Duke Comprehensive Cancer Center

Recent Publications: 

Combining temperature and force to study folding of an RNA hairpin.
Stephenson W, Keller S, Santiago R, Albrecht JE, Asare-Okai PN, Tenenbaum SA, Zuker M, Li PT.
Phys Chem Chem Phys. 2013 Nov 25. [Epub ahead of print]

Profiling post-transcriptionally networked mRNA subsets using RIP-Chip and RIP-Seq.
Jayaseelan S, Doyle F, Tenenbaum SA.
Methods. 2013 Nov 17. doi:pii: S1046-2023(13)00430-1. 10.1016/j.ymeth.2013.11.001. [Epub ahead of print]

The essential role of stacking adenines in a two-base-pair RNA kissing complex.
Stephenson W, Asare-Okai PN, Chen AA, Keller S, Santiago R, Tenenbaum SA, Garcia AE, Fabris D, Li PT.
J Am Chem Soc. 2013 Apr 17;135(15):5602-11. doi: 10.1021/ja310820h. Epub 2013 Apr 8. 

Neurodevelopmental disorders: Signalling pathways of fragile X syndrome. Jayaseelan S, Tenenbaum SA. Nature. 2012 Dec 20;492(7429):359-60.

An integrated encyclopedia of DNA elements in the human genome. ENCODE Project Consortium, Dunham I, et al., Nature. 2012 Sep 6;489(7414):57-74.

Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression. Kusek G, Campbell M, Doyle F, Tenenbaum SA, Kiebler M, Temple S. Cell Stem Cell. 2012 Oct 5;11(4):505-16.

An in-depth map of polyadenylation sites in cancer. Lin Y, Li Z, Ozsolak F, Kim SW, Arango- Argoty G, Liu TT, Tenenbaum SA, Bailey T, Monaghan AP, Milos PM, John B. Nucleic Acids Res. 2012 Sep 1;40(17):8460-71.

Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning. Lapidus KA, Nwokafor C, Scott D, Baroni TE, Tenenbaum SA, Hiroi N, Singer RH, Czaplinski K. Learn Mem. 2012 Jan 12;19(2):35-42.

Dutasteride monotherapy in men with serologic relapse following radical therapy for adenocarcinoma of the prostate: a pilot study. Perrotti M, Jain R, Abriel LM, Baroni TE, Corbett AB, Tenenbaum SA. Urol Oncol. 2012 Mar-Apr;30(2):133-8 

Dutasteride monotherapy in men with serologic relapse following radical therapy for adenocarcinoma of the prostate: A pilot study. Perrotti M, Jain R, Abriel LM, Baroni TE, Corbett AB, Tenenbaum SA. Urol Oncol. 2010 Aug 25.

RIP-CHIP in drug development. Jain R, Doyle F, George AD, Kuentzel M, Frank D, Chittur SV, Tenenbaum SA. Methods Mol Biol. 2010;632:159-7

Informatic resources for identifying and annotating structural RNA motifs. George AD, Tenenbaum SA. Mol Biotechnol. 2009 Feb;41(2):180-93.

George, A.D., and Tenenbaum, S.A. (2008). Informatic Resources for Identifying and Annotating Structural RNA Motifs. Mol Biotechnol. 2008 Nov 1. [Epub ahead of print] 

Baroni, T. E., Chittur, S. V., George, A. D. and Tenenbaum, S. A. (2008). Advances in RIP-Chip Analysis: RNA-Binding Protein Immunoprecipitation-Microarray (Chip) Profiling.  Methods Mol Biol. 2008;419:93-108.

Stoecklin G, Tenenbaum S. A., Mayo T, Chittur SV, George AD, Baroni TE, Blackshear PJ and Anderson, P. (2008). Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem. Apr 25;283(17):11689-99.  

Doyle, F., Zaleski, C., George, A.D., Stenson, E.K., Ricciardi, A. and Tenenbaum, S. A. (2008). Bioinformatic Tools for Studying Post-Transcriptional Gene Regulation:  The UAlbanyTUTR (Training UTR) Collection and other Informatic Resources. Methods Mol Biol. 2008;419:39-52.

Mazroui R, Di Marco S, Clair E, von Roretz C, Tenenbaum S. A., Keene JD, Saleh M, Gallouzi IE. (2008). Caspase-7-mediated Cleavage of the RNA-binding Protein HuR is a Novel Regulatory Mechanism Required for Apoptosis. J Cell Biol.  180(1):113-27. 

Baroni, T. E., Lastro, M. T., Ranganathan, A. C., Tenenbaum, S. A., Conklin, D. S. and Aguirre-Ghiso, J. A. (2007). Ribonomic and Short Hairpin RNA Gene Silencing Methods to Explore Functional Gene Programs Associated with Tumor Growth Arrest Methods in Molecular Biology: Cancer Genomics and Proteomics vol.383: 227-244.

George, A.D., and Tenenbaum, S.A. (2006). MicroRNA Modulation of RNA-Binding Protein Regulatory Elements. RNA Biology 3(2): 1-4. 

Tenenbaum, S. A. and Aguirre-Ghiso, J.A. (2005). Dephosphorylation Shows SR Proteins the Way Out. Mol. Cell. 23;20(4):499-501.

Sander DM, Szabo S, Gallaher WR, Deas JE, Thompson JJ, Cao Y, Luo-Zhang H, Liu LG, Colmegna I, Koehler J, Espinoza LR, Alexander SS, Hart DJ, Tom DM, Fermin CD, Jaspan JJ, Kulakosky PC, Tenenbaum S.A., Wilson RB, Garry RF. (2005). Involvement of human intracisternal A-type retroviral particles in autoimmunity. Microsc Res Tech. 68:222-34. 

Tenenbaum S.A., Morris CA, Alexander SS, McFerrin HE, Garry RF, Leissinger CA. (2005). Evidence of HIV exposure and transient seroreactivity in archived HIV-negative severe hemophiliac sera. Virol J. 17; 2:65.

Di-Marco, S.,  Mazroui, R.,  Dallaire, P., Chittur, S., Tenenbaum, S.A.,  Radzioch, D., Marette A., and Gallouzi, I.E. (2005). NF-kB-Mediated MyoD Decay during Muscle Wasting Requires Nitric Oxide Synthase mRNA Stabilization, HuR Protein, and Nitric Oxide Release. Mol Cell Biol. 15: 6533-45. 

Penalva, L.O., Tenenbaum, S.A., and  Keene, J.D. (2004). Gene Expression Analysis of Messenger RNP Complexes. Methods Mol Biol. 257:125-34.

Intine, R.V., Tenenbaum, S.A., Sakulich, A.L., Keene, J.D., and Maraia, R.J. (2003). Differential phosphorylation and subcellular localization of LaRNPs associated with precursor tRNAs and translation-related mRNAs. Molecular Cell 12: 1301-1307. 

Tenenbaum, S.A., Carson C.C., Atasoy, U., and Keene, J.D. (2003). Combining en masse array analysis of gene regulation using genome-wide approaches to nuclear run-ons (emRON) and mRNP isolation (ribonomics). Gene 317: 79-87. 


  • Tenenbaum, S.A., Hauser, J.M., Castracane, J., Tokranova, N., Padgen, M.R. and Baroni, T. High-Throughput Nanoscale Immunoassy Platform.  Provisional Patent Application # 61138391
  • Tenenbaum, S.A., Zaleski, C., George, A.D., and Doyle, F.  Non-Random Control Data Set Generation for Facilitating Genomic Data Processing.  Provisional Patent Application # 60/917,158 (Pending license to HocusLocus, LLC, Rensselaer, NY). Filed 2007.
  • Tenenbaum, S.A., Zaleski, C., George, A.D., and Doyle, F. Segmented Storage and Retrieval of Nucleotide Sequence Information.  Provisional Patent Application # 60/917,157 (Pending license to HocusLocus, LLC, Rensselaer, NY). Filed 2007.
  • Tenenbaum, S.A., Zaleski, C., George, A.D., and Doyle, F.  Genomic Data Processing Utilizing Correlation Analysis of Nucleotide Loci of Multiple Data Sets. Patent Application # 60/917,156 (Pending license to HocusLocus, LLC, Rensselaer, NY). Filed 2007.
  • Tenenbaum, S.A., Zaleski, C., George, A.D., and Doyle, F. Genomic Data Processing Utilizing Correlation Analysis of Nucleotide Loci. Provisional Patent Application # 60/917,155 (Pending license to HocusLocus, LLC, Rensselaer, NY), Filed 2007.
  • Tenenbaum, S.A., Conklin, D.S., Kourtidis, A., George, A.D., Zaleski, C., Baroni, T., and Doyle, F. Compositions and Methods for Treating Viral Infections. Provisional Patent Application # 61/023,933 (Pending license to HocusLocus, LLC, Rensselaer, NY). Filed 2008.
  • Warren, S.T., Brown-kennerly, V., Jin, P., Ceman, S., Darnell, R.B., Darnell, J.C., Keene, J.D., and Tenenbaum, S. A. Method and identification of downstream mrna ligands to fmrp and their role in fragile x syndrome and associated disorders. USP# 7432052.
  • Keene, J.D., Carson, C.C. and Tenenbaum, S.A.  Methods for the Endogenous Isolation and Identification of Messenger RNA SubsetsUSP# 6,635,422 (Licensed to Ribonomics Inc., Triangle Park, NC).
  • Garry, R.F., Tenenbaum, S. A., and Plymale, D. R.  Method to Aid in the Diagnosis of Silicone Related Disease.  USP# 5,620,859 (Licensed to Autoimmune Inc., New Orleans, LA).
  • Garry, R.F., Tenenbaum, S. A., and Plymale, D. R. Method for detecting antipolymer antibodies and diagnosing silicone related disease (SRD) fibromyalgia and chronic fatigue syndrome (CFS). USP#5834215 (Licensed to Autoimmune Inc., New Orleans, LA, International patent pending).

Recent Invited Lectures and Presentations

  • Nanomedicine Development Center, University of Cincinnati, Cincinnati, OH, 2010
  • Children's Cancer Research Institute - UTHSCSA, San Antonio, TX, 2010
  • The ENCODE Project, Barcelona, Spain, 2010
  • Sanford Burnham Institute, Orlando FL, 2010
  • Sigma Aldrich, St. Louis, MO, 2010
  • Cell Culture Engineering XII, Fairmont Banff Springs Hotel, Banff, Alberta, Canada, 2010
  • Systems Biology Meeting, Cold Spring Harbor, NY, 2010
  • Millipore Future Forum II, Bedford, MA, 2010
  • Systems Biology of Human Aging Symposium, NIA/NIH, Baltimore, MD, 2009
  • Boston College, Department of Biology, Boston, MA, 2009
  • Millipore Future Forum, Boston, MA, 2009
  • Millipore BioAsia Tour, Tokyo, Japan, Seoul, Korea and Shanghai, China, 2009
  • University of Toronto, Institute of Biomaterials & Biomedical Engineering, Toronto, Canada, 2009 
  • Yale University Medical Center, Department of Hematology, New Haven, CT FASEB Meeting Post-transcriptional Control of Gene Expression, Lucca, Italy, 2008
  • The Biology of Genomes Meeting, Cold Spring Harbor, NY, 2008
  • Workshop on Post-transcriptional regulation of viral gene expression, Syria, VA, 2008
  • modENCODE/ENCODE Joint Consortium Workshop, Bethesda, MD, 2008
  • Harvard Medical School, Department of Systems Biology, Cambridge, MA, 2007
  • The 12th Annual RNA Society Conference, Madison, WI, 2007
  • Systems Biology Meeting, Cold Spring Harbor, NY, 2007
  • New York Academy of Sciences, New York, NY, 2007
  • Kavli Institute for Theoretical Physics, Santa Barbara, CA, 2007 
  • Boston University Medical Center, Department of Pulmonology, Boston, MA, 2007
  • University of Pennsylvania Medical Center, Dept. of Pharmacology, Philadelphia, PA, 2006
  • Genomic Institute of Singapore, Department of Systems Biology, Singapore, 2006
  • Institute for Immunologic Studies, Kyoto University, Japan, 2006
  • Center for Genomics and Systems Biology, Tokyo University, Japan, 2006
  • I2CAM Landscape Networks Meeting, Telluride, CO, 2006
  • Advances in Functional Genomics Conference, San Francisco, CA, 2006
  • University of Calgary, Department of Rheumatology, Alberta, Canada, 2006